Abstract
The lbp gene, which encodes a laminin-binding protein (Lbp) of Streptococcus pyogenes, was found in all S. pyogenes M types. An Lbp-deficient mutant showed a significantly lower efficiency of adhesion to HEp-2 cells than did the wild-type strain. These results indicate that Lbp is one of the important S. pyogenes adhesins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Adhesion / physiology*
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Bacterial Proteins / classification
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Bacterial Proteins / physiology*
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Base Sequence
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DNA, Bacterial
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Epithelial Cells / microbiology
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Genome, Bacterial
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Humans
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Laminin / metabolism*
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Molecular Sequence Data
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Open Reading Frames
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Receptors, Laminin / classification
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Receptors, Laminin / genetics
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Receptors, Laminin / metabolism
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Receptors, Laminin / physiology*
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Streptococcus pyogenes / genetics
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Streptococcus pyogenes / metabolism
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Streptococcus pyogenes / physiology*
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Tumor Cells, Cultured
Substances
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Bacterial Proteins
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DNA, Bacterial
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Laminin
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Lbp protein, Streptococcus
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Receptors, Laminin