Reduction of serum interferon (IFN)-gamma concentration and lupus development in NZBxNZWF(1)mice by lactic dehydrogenase virus infection

J Comp Pathol. 2001 Nov;125(4):285-91. doi: 10.1053/jcpa.2001.0507.


The complexity of cytokine regulation and the imbalance of helper T (Th)1 and Th2 subsets in systemic lupus erythematosus (SLE) animal models and human SLE are well recognized. In this study in NZBxNZWF(1)mice, the effects of lactic dehydrogenase virus (LDV) infection on the production of interferon (IFN)-gamma in the serum and the development of autoimmune disease were examined. The progress of the disease (the development of glomerulonephritis, formation of glomerular IgG and C3 deposits, increase in the blood urea nitrogen values, and mortality) was parallel with an increase in serum IFN-gamma in uninfected NZBxNZWF(1)mice. These changes were inhibited in LDV-infected NZBxNZWF(1)mice. Our findings suggest that increase in serum IFN-gamma may be associated with the active disease in NZBxNZWF(1)mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arterivirus Infections / complications*
  • Arterivirus Infections / mortality
  • Arterivirus Infections / pathology
  • Blood Urea Nitrogen
  • Complement C3 / metabolism
  • Disease Models, Animal
  • Female
  • Fluorescent Antibody Technique
  • Fluorescent Antibody Technique, Direct
  • Glomerulonephritis / metabolism
  • Glomerulonephritis / pathology
  • Glomerulonephritis / virology
  • Immunoglobulin E / blood
  • Immunoglobulin G / metabolism
  • Interferon-gamma / blood
  • Kidney Glomerulus / metabolism
  • Kidney Glomerulus / pathology
  • Lactate dehydrogenase-elevating virus / pathogenicity
  • Lactate dehydrogenase-elevating virus / physiology*
  • Lupus Erythematosus, Systemic / mortality
  • Lupus Erythematosus, Systemic / pathology
  • Lupus Erythematosus, Systemic / virology*
  • Mice
  • Mice, Inbred NZB
  • Survival Rate


  • Complement C3
  • Immunoglobulin G
  • Immunoglobulin E
  • Interferon-gamma