Synthesis of boroxifen, a nido-carborane analogue of tamoxifen

J Org Chem. 2002 Jan 25;67(2):383-7. doi: 10.1021/jo0158229.


A nido-carborane analogue of tamoxifen, the widely employed breast cancer therapy agent, was prepared as an archetype of a potential new class of antiestrogen and boron neutron capture therapy agent in which the carborane is incorporated within the framework of the parent compound. The carborane was introduced through the reaction of 6,9-bis(acetonitrile)decaborane with a unique and highly conjugated ene-yne, which was prepared stereoselectively. NMR spectroscopy and a crystal structure of a key intermediate, the carborane analogue of chloro-tamoxifen, demonstrated the structural similarities between the tamoxifen carboranes and their corresponding phenyl analogues.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry*
  • Boron Compounds / chemistry
  • Boron Neutron Capture Therapy
  • Catalysis
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, High Pressure Liquid
  • Estrogen Receptor Modulators / chemical synthesis*
  • Estrogen Receptor Modulators / chemistry
  • Estrogen Receptor Modulators / classification
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Spectroscopy, Fourier Transform Infrared
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tamoxifen* / analogs & derivatives
  • Tamoxifen* / chemical synthesis*
  • Tamoxifen* / chemistry


  • Antineoplastic Agents
  • Boron Compounds
  • Estrogen Receptor Modulators
  • boroxifen
  • Tamoxifen