[Effect of mecobalamin on diabetic neuropathies. Beijing Methycobal Clinical Trial Collaborative Group]

Zhonghua Nei Ke Za Zhi. 1999 Jan;38(1):14-7.
[Article in Chinese]


Objective: To investigate the effect of mecobalamin on diabetic neuropathies.

Methods: One hundred and eight patients with non-insulin dependent diabetes mellitus were involved in a randomized positive-control clinical trial. 62 cases were treated with mecobalamin 500 microg intramuscularly three times a week for four weeks then followed by 500 microg orally three times a day for additional eight weeks. 46 cases were treated with vitamin B(12) in the same way and served as controls.

Results: Twelve weeks after the treatment, spontaneous pain and numbness of limbs were improved by 73% and 75% in the mecobalamin group, which were much higher than those in the controls (36% and 45% respectively). Hypoesthesia, hotness, coldness, oral dryness and dysuria showed better response in the mecobalamin group than in the controls (55% vs 25%, 52% vs 18%, 59% vs 30%, 53% vs 19%, 63% vs 20% respectively). Mecobalamin also benefited nerve reflection and conduction velocity to a certain extent. No obvious side effects were found.

Conclusion: Mecobalamin might be worthy of use as a safe agent in the treatment of diabetic neuropathies.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetic Neuropathies / drug therapy*
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / therapeutic use*
  • Vitamin B 12 / administration & dosage
  • Vitamin B 12 / analogs & derivatives*
  • Vitamin B 12 / therapeutic use


  • Neuroprotective Agents
  • mecobalamin
  • Vitamin B 12