[An Analysis of the Therapeutic Effects and Reactions in Treating Acute Promyelocytic Leukemia With Intravenous Arsenic Trioxide or All-Trans Retinoic Acid]

Zhonghua Nei Ke Za Zhi. 1999 Feb;38(2):113-5.
[Article in Chinese]

Abstract

Objective: To compare the therapeutic effects and reactions of intra venous arsenic trioxide and all-trans retinoic acid in treating patients with acute promyelocytic leukemia (APL).

Methods: 75 cases of APL were randomized either to arsenic trioxide (37) or to all-trans retinoic acid (38). The rates of complete remission (CR), disease free survival (DFS) and side effects were observed.

Results: In the two groups of patients with APL, the rate of CR was 86.4% and 84.2%. There was also no significant difference in the rate of DSF phase of CR (P > 0.05). The side effects of these two medications in therapeutic dose were mild and there was no cross resistance between them.

Conclusion: Arsenic trioxide can lead to apoptosis of leukemic cells and might be a new promising drug to induce differentiation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Antineoplastic Agents / adverse effects
  • Antineoplastic Agents / therapeutic use*
  • Apoptosis / drug effects
  • Arsenic Trioxide
  • Arsenicals / adverse effects
  • Arsenicals / therapeutic use*
  • Child
  • Disease-Free Survival
  • Female
  • Humans
  • Leukemia, Promyelocytic, Acute / drug therapy*
  • Leukemia, Promyelocytic, Acute / pathology
  • Male
  • Middle Aged
  • Oxides / adverse effects
  • Oxides / therapeutic use*
  • Tretinoin / adverse effects
  • Tretinoin / therapeutic use*

Substances

  • Antineoplastic Agents
  • Arsenicals
  • Oxides
  • Tretinoin
  • Arsenic Trioxide