Se-methylselenocysteine: A New Compound for Chemoprevention of Breast Cancer

Nutr Cancer. 2001;40(1):12-7. doi: 10.1207/S15327914NC401_5.


Selenium compounds have attracted renewed interest as chemopreventive agents for human cancer on the basis of the pioneering intervention study by Clark and co-workers. The rodent mammary gland has been used extensively as a model for examining the chemopreventive activities of inorganic and organic selenium compounds. This review summarizes the rationale and results for use of a new organic selenium compound, Se-methylselenocysteine, which exhibits greater efficacy as a chemopreventive agent than several previously used selenium compounds in experimental models of breast cancer and has potential for use in human populations.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / therapeutic use*
  • Breast Neoplasms / prevention & control*
  • Cysteine / analogs & derivatives*
  • Cysteine / therapeutic use*
  • Disease Models, Animal
  • Female
  • Humans
  • Mammary Neoplasms, Experimental / prevention & control*
  • Organoselenium Compounds / therapeutic use*
  • Selenocysteine / analogs & derivatives
  • Treatment Outcome


  • Anticarcinogenic Agents
  • Organoselenium Compounds
  • Selenocysteine
  • Cysteine
  • selenomethylselenocysteine