The biliary excretion of 3H-inulin and 3H-terbutaline in the unanesthetized rat

Acta Physiol Scand. 1975 Sep;95(1):1-5. doi: 10.1111/j.1748-1716.1975.tb10017.x.


An animal model which permits sampling of arterial blood and bile from unanesthetized rats with uninterrupted enterohepatic circulation is described. Pharmacokinetic data concerning inulin (0.2 mumol kg-1) and terbutaline (1.8 mumol kg-1) after intraarterial injection are presented. The following values for inulin were obtained Vdbeta equals 0.25 ml g-1, plasma clearance equals 2.3 ml min-1 kg-1 and bile clearance equals 0.03-0.04 ml min-1 kg-1, which mainly are in agreement with data from the literature. For terbutaline the corresponding values were 0.58 ml g-1, 5.2 ml min-1 kg-1 and 0.12-0.98 ml min-1 kg-1, respectively.

MeSH terms

  • Animals
  • Bile* / analysis
  • Inulin / blood
  • Inulin / metabolism*
  • Liver / metabolism*
  • Male
  • Metabolic Clearance Rate
  • Rats
  • Terbutaline / blood
  • Terbutaline / metabolism*
  • Time Factors


  • Inulin
  • Terbutaline