Epigenetics as a first exit problem

Phys Rev Lett. 2002 Jan 28;88(4):048101. doi: 10.1103/PhysRevLett.88.048101. Epub 2002 Jan 8.

Abstract

We develop a framework to discuss the stability of epigenetic states as first exit problems in dynamical systems with noise. We consider in particular the stability of the lysogenic state of the lambda prophage. The formalism defines a quantitative measure of robustness of inherited states.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacteriophage lambda / genetics
  • Bacteriophage lambda / metabolism
  • Binding Sites
  • DNA, Viral / genetics
  • DNA, Viral / metabolism
  • DNA-Binding Proteins / metabolism
  • Escherichia coli / virology
  • Gene Expression Regulation, Viral*
  • Lysogeny / genetics
  • Models, Genetic*
  • Repressor Proteins / metabolism
  • Viral Proteins / metabolism
  • Viral Regulatory and Accessory Proteins

Substances

  • DNA, Viral
  • DNA-Binding Proteins
  • Repressor Proteins
  • Viral Proteins
  • Viral Regulatory and Accessory Proteins
  • phage repressor proteins