Histamine content and synthesis in central and pheripheral nerve structures during stress

Agents Actions. 1975 Feb;5(1):4-8. doi: 10.1007/BF02027150.


Histamine content and histidine decarboxylase activity in cortex and hypothalamus, together with histamine content in peripheral nervous structures were examined in normal and electrically stressed guinea-pigs. A significant increase in histidine decarboxylase activity in hypothalamus and cortex together with concomitant decrease in histamine content in hypothalamus have been found. Electric shock causes also a decrease in histamine content in spinal cord, spinal ganglia, dorsal roots and sensory nerve. The function of histamine in nervous system is discussed.

MeSH terms

  • Animals
  • Cerebral Cortex / metabolism
  • Electric Stimulation
  • Female
  • Guinea Pigs
  • Histamine / biosynthesis*
  • Histidine Decarboxylase / metabolism
  • Hypothalamus / metabolism
  • Nerve Tissue / enzymology
  • Nerve Tissue / metabolism*
  • Stress, Physiological / metabolism*


  • Histamine
  • Histidine Decarboxylase