Ber-EP4 and MNF-116 in a previously undescribed morphologic pattern of granular basal cell carcinoma

Am J Dermatopathol. 2001 Dec;23(6):530-2. doi: 10.1097/00000372-200112000-00006.


Granular basal cell carcinoma (GBCC) is a rare subtype of basal cell carcinoma (BCC) with only seven previously described cases in the literature. A 65-year-old man presented with a papule on his cheek that was subsequently removed. Histopathologic examination revealed that the neoplasm had no connection to the overlying epidermis and that the neoplasm had two different morphologies; nodules composed solely of granular cells and other nodules with a rim of basaloid cells and central granular cells. The neoplasm stained for both Ber-EPF4 and MNF-116 thus confirming it as a subtype of BCC. GBCC should be considered in the differential diagnosis of nodular neoplasms containing granular cells.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal / analysis*
  • Antigens, Surface / analysis*
  • Biomarkers, Tumor / analysis*
  • Carcinoma, Basal Cell / chemistry
  • Carcinoma, Basal Cell / pathology*
  • Granular Cell Tumor / pathology
  • Humans
  • Keratinocytes / chemistry
  • Male
  • Skin Neoplasms / chemistry
  • Skin Neoplasms / pathology*


  • Antibodies, Monoclonal
  • Antigens, Surface
  • Biomarkers, Tumor
  • human epithelial antigen-125