Enhancement of salivary secretion and neuropeptide (substance P, alpha-calcitonin gene-related peptide) levels in saliva by chronic anethole trithione treatment

J Pharm Pharmacol. 2001 Dec;53(12):1697-702. doi: 10.1211/0022357011778098.

Abstract

Anethole trithione, a choleretic, has been reported to be effective in the treatment of dry mouth. We have examined the effects of chronic treatment with anethole trithione on salivary secretion, substance P immunoreactive substance (SP-IS) and alpha-calcitonin gene-related peptide immunoreactive substance (alpha-CGRP-IS) concentrations in human saliva. Anethole trithione caused significant increases of saliva SP-IS concentrations from the day 13 (25.3 +/- 1.6 pg mL(-1)) to day 14 (25.8 +/- 1.7 pg mL(-1)) compared with day 1 (19.9 +/- 1.9 pg mL(-1)). Anethole trithione caused significant increase in saliva alpha-CGRP-IS concentration on day 14 (39.9 +/- 4.7 pg mL(-1)) compared with day 1 (27.7 +/- 4.7 pg mL(-1)). Anethole trithione significantly increased the sialosis volumes from day 11 to day 14 (1.6 +/- 0.1-1.7 +/- 0.2 mL) compared with the day 1 (1.2 +/- 0.2 mL). Simple linear regression of the increase in sialosis volume with saliva SP-IS (r = 0.94) and alpha-CGRP-IS (r = 0.97) concentrations was found. These results demonstrated that chronic treatment with anethole trithione affected saliva SP-IS and alpha-CGRP-IS concentration in human saliva and sialosis volume.

MeSH terms

  • Adult
  • Anethole Trithione / blood
  • Anethole Trithione / pharmacology*
  • Calcitonin Gene-Related Peptide / analysis*
  • Calcitonin Gene-Related Peptide / immunology
  • Cholagogues and Choleretics / pharmacology*
  • Humans
  • Immunoenzyme Techniques
  • Male
  • Peptide Fragments / analysis*
  • Peptide Fragments / immunology
  • Saliva / chemistry
  • Saliva / drug effects*
  • Saliva / metabolism
  • Substance P / analysis*
  • Substance P / immunology

Substances

  • Cholagogues and Choleretics
  • Peptide Fragments
  • calcitonin gene-related peptide (8-37)
  • Substance P
  • Calcitonin Gene-Related Peptide
  • Anethole Trithione