Remodeling for Demolition: Changes in Mitochondrial Ultrastructure During Apoptosis

Mol Cell. 2002 Jan;9(1):1-3. doi: 10.1016/s1097-2765(02)00437-9.


The release of Cytochrome c from mitochondria is a pivotal event in the apoptotic process, but the precise mechanisms remain controversial. A recent paper proposes that this involves two steps, one involving permeabilization of the mitochondrial outer membrane and a second in which the structural organization of the cristae changes to make Cytochrome c accessible for release. Both events are induced by proapoptotic members of the Bcl-2 family and appear to be separable.

MeSH terms

  • Animals
  • Apoptosis*
  • Cytochrome c Group / metabolism
  • Mitochondria / metabolism
  • Mitochondria / ultrastructure*
  • Mitochondrial Swelling


  • Cytochrome c Group