(-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions

Trends Pharmacol Sci. 2002 Jan;23(1):4-7. doi: 10.1016/s0165-6147(00)01929-5.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / pharmacology*
  • Antipsychotic Agents / therapeutic use
  • Basal Ganglia / metabolism
  • Berberine / adverse effects
  • Berberine / analogs & derivatives
  • Berberine / pharmacology*
  • Berberine / therapeutic use
  • Clinical Trials as Topic
  • Dopamine / metabolism
  • Dopamine Agents / adverse effects
  • Dopamine Agents / pharmacology*
  • Dopamine Agents / therapeutic use
  • Dopamine D2 Receptor Antagonists*
  • Humans
  • Neurons / metabolism
  • Nucleus Accumbens / metabolism
  • Prefrontal Cortex / metabolism
  • Receptors, Dopamine D1 / agonists*
  • Schizophrenia / drug therapy
  • Synaptic Transmission
  • Ventral Tegmental Area / metabolism

Substances

  • Antipsychotic Agents
  • Dopamine Agents
  • Dopamine D2 Receptor Antagonists
  • Receptors, Dopamine D1
  • Berberine
  • stepholidine
  • Dopamine