RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction

Mech Dev. 2002 Feb;111(1-2):177-80. doi: 10.1016/s0925-4773(01)00616-5.


RanBP1, a velocardiofacial syndrome/DiGeorge syndrome candidate gene, is expressed in the frontonasal processes, branchial arches, aortic arches, and limb buds. At these sites, RanBP1 apparently coincides with neural crest-derived mesenchymal cells. In addition, RanBP1 is expressed in the forebrain as well as in hindbrain regions previously associated with crest-derived mesenchymal cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aorta / embryology
  • DiGeorge Syndrome / genetics
  • Embryonic Induction / genetics
  • Epithelium / embryology*
  • Female
  • Gene Expression Regulation, Developmental
  • Humans
  • Limb Buds
  • Mesoderm*
  • Mice
  • Mice, Inbred ICR
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • ran GTP-Binding Protein / genetics*
  • ran GTP-Binding Protein / metabolism


  • Nuclear Proteins
  • ran-binding protein 1
  • ran GTP-Binding Protein

Associated data

  • OMIM/188400
  • OMIM/192430