The mechanism of action of amantadine in Parkinsonism: a review

Arch Int Pharmacodyn Ther. 1975 Aug;216(2):246-62.

Abstract

Studies of the mechanism of action of amantadine are reviewed. Data from pharmacological, behavioural and neurochemical experiments seem to indicate that the most likely effects of amantadine to be important in the alleviation of Parkinsonian symptoms are an indirect dopamine-releasing action and a direct stimulation of dopamine receptors. These effects may have a relative importance of approximately 4 : 1. Evidence favouring inhibition of dopamine uptake does exist, but the balance of opinion seems to be that this action is far too weak to contribute substantially to amantadine's action in vivo.

MeSH terms

  • Amantadine / pharmacology*
  • Amantadine / therapeutic use
  • Amines / metabolism
  • Animals
  • Behavior, Animal / drug effects
  • Body Temperature / drug effects
  • Catecholamines / biosynthesis
  • Catecholamines / metabolism
  • Central Nervous System / drug effects
  • Conditioning, Psychological / drug effects
  • Depression, Chemical
  • Dogs
  • Electroencephalography
  • Humans
  • Mice
  • Motor Activity / drug effects
  • Neurons / drug effects
  • Parkinson Disease / drug therapy*
  • Rabbits
  • Rats
  • Stereotyped Behavior / drug effects

Substances

  • Amines
  • Catecholamines
  • Amantadine