Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members

Annu Rev Pharmacol Toxicol. 2002;42:283-323. doi: 10.1146/annurev.pharmtox.42.090401.151133.


Cellular interactions with the extracellular matrix and with neighboring cells profoundly influence a variety of signaling events including those involved in mitogenesis, survival, and differentiation. Recent advances have provided insights into mechanisms underlying the ability of integrins, cadherins, selectins, and other cell adhesion molecules to regulate signal transduction cascades. These mechanisms often involve the ability of cell adhesion molecules to initiate the formation of organized structures or scaffolds that permit the efficient flow of information in signaling pathways.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cadherins / physiology*
  • Cytoskeleton / physiology*
  • Integrins / physiology*
  • MAP Kinase Signaling System / physiology
  • Neural Cell Adhesion Molecules / physiology
  • Proteoglycans / physiology
  • Receptors, Cytokine / physiology
  • Selectins / physiology*
  • Signal Transduction*
  • rho GTP-Binding Proteins / physiology


  • Cadherins
  • Integrins
  • Neural Cell Adhesion Molecules
  • Proteoglycans
  • Receptors, Cytokine
  • Selectins
  • rho GTP-Binding Proteins