Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Jan 24;415(6870):389-95.
doi: 10.1038/415389a.

Antimicrobial Peptides of Multicellular Organisms

Affiliations

Antimicrobial Peptides of Multicellular Organisms

Michael Zasloff. Nature. .

Abstract

Multicellular organisms live, by and large, harmoniously with microbes. The cornea of the eye of an animal is almost always free of signs of infection. The insect flourishes without lymphocytes or antibodies. A plant seed germinates successfully in the midst of soil microbes. How is this accomplished? Both animals and plants possess potent, broad-spectrum antimicrobial peptides, which they use to fend off a wide range of microbes, including bacteria, fungi, viruses and protozoa. What sorts of molecules are they? How are they employed by animals in their defence? As our need for new antibiotics becomes more pressing, could we design anti-infective drugs based on the design principles these molecules teach us?

Similar articles

See all similar articles

Cited by 1,791 articles

See all "Cited by" articles

LinkOut - more resources

Feedback