The antiulcer activity of Garcinia cambogia extract against indomethacin-induced gastric ulcer in rats

Phytother Res. 2002 Feb;16(1):80-3. doi: 10.1002/ptr.946.


Garcinia cambogia extract is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. In the present study this drug was tested for its antiulcerogenic effect. Oral pretreatment with Garcinia cambogia fruit extract (1 g/kg body wt/day) for 5, 10 or 15 days protected the gastric mucosa against the damage induced by indomethacin (20 mg/kg body wt). The volume and acidity of the gastric juice decreased in the pretreated rats. The glycoprotein levels of the gastric contents which were decreased in the untreated rats, maintained near normal levels in the pretreated rats. Protein which was elevated in the gastric juice of untreated rats, showed near normal levels in the pretreated rats. Garcinia cambogia was able to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Ulcer Agents / pharmacology*
  • Anti-Ulcer Agents / therapeutic use
  • Fruit / chemistry
  • Garcinia cambogia*
  • Gastric Acidity Determination
  • Gastric Mucosa / drug effects
  • Glycoproteins / metabolism
  • Indomethacin / toxicity
  • Male
  • Peptic Ulcer / chemically induced
  • Peptic Ulcer / drug therapy*
  • Phytotherapy*
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Proteins / metabolism
  • Rats
  • Rats, Wistar


  • Anti-Ulcer Agents
  • Glycoproteins
  • Plant Extracts
  • Proteins
  • Indomethacin