Abstract
In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.
Copyright 2002 John Wiley & Sons, Ltd.
MeSH terms
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Abies*
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Abietanes*
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology*
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Linoleic Acid / pharmacology
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Lipoxygenase / metabolism*
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Molecular Structure
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification
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Phenanthrenes / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
Substances
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Abietanes
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Diterpenes
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Enzyme Inhibitors
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Phenanthrenes
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Plant Extracts
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Linoleic Acid
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Lipoxygenase
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abietic acid