Paroxysmal tonic upgaze of childhood: effect of age-of-onset on prognosis

Acta Paediatr. 2001 Nov;90(11):1343-5. doi: 10.1080/080352501317130443.


Paroxysmal tonic upgaze (PTU) is a syndrome of childhood manifesting as sudden ocular movements with sustained upward deviation of the eyes. We describe the outcome of 6 patients, after a follow-up of 10 years, with onset of the disease in childhood. The aims of this study were to clarify some clinical features of this syndrome and to evaluate the long-term prognosis of these children. In all the patients, tonic upgaze episodes disappeared with time to remission, varying from 1 to 4 y, without any therapy and without any change in psychomotor development, EEG and neuroimaging. Only one child had pathologic interictal EEG with temporo-occipital spikes, which persisted after the offset of the disease.

Conclusion: From a long-term follow-up, we can confirm the good prognosis of PTU and suggest it is possible to define a distinct syndrome of childhood without any neurological abnormalities and with spontaneous resolution.

Publication types

  • Case Reports

MeSH terms

  • Age of Onset
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Italy
  • Male
  • Neurologic Examination
  • Ocular Motility Disorders / diagnosis*
  • Prognosis
  • Psychomotor Performance
  • Syndrome