Characterization of the collagen of human hypertrophic and normal scars

Biochim Biophys Acta. 1975 Oct 20;405(2):412-21. doi: 10.1016/0005-2795(75)90106-3.


The collagen produced in response to an injury of human skin is initially stabilized by a cross-link derived from hydroxyallysine, and characteristic of embryonic skin. In normal healing there is a change over with time to the cross-link derived from allysine, which is typical of young skin collagen. In contrast, hypertrophic scars fail to follow the time-related changes of normal skin, but retain the characteristics of embryonic collagen, indicating a continued rapid turnover of the collagen. This is further supported by the high proportion of the embryonic Type III collagen present in hypertrophic scars.

MeSH terms

  • Adolescent
  • Adult
  • Amino Acids / analysis
  • Child
  • Cicatrix / pathology*
  • Collagen / analysis*
  • Elastin / analysis
  • Humans
  • Hydroxylysine / analysis
  • Hypertrophy
  • Macromolecular Substances
  • Middle Aged
  • Protein Binding
  • Skin / analysis*
  • Solubility
  • Time Factors
  • Water / analysis


  • Amino Acids
  • Macromolecular Substances
  • Water
  • Hydroxylysine
  • Collagen
  • Elastin