Amplification and overexpression of c-met gene in Epstein-Barr virus-associated gastric carcinomas

Oncology. 2002;62(1):60-5. doi: 10.1159/000048248.


To reveal the role of oncogenes in Epstein-Barr virus (EBV)-positive gastric carcinomas, the amplification and overexpression of the c-met gene were examined by a competitive polymerase chain reaction and immunohistochemistry, respectively. The proportion of c-met amplification and overexpression in EBV-positive and -negative carcinomas did not differ significantly. The amplification and overexpression of the c-met gene in EBV-negative gastric carcinomas were significantly associated with upper location, deeper invasion and lymphatic invasion, while in EBV-positive gastric carcinomas a significant correlation with c-met activation was observed only in deeper invasion. However, none of the observed associations of c-met amplification or overexpression with clinicopathological features in the EBV-positive and -negative carcinomas differed significantly in their strength or direction. These results suggest that the amplification and overexpression of c-met gene do not play a different role in the progression and metastasis of EBV-positive and EBV-negative gastric carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Female
  • Gene Amplification / genetics*
  • Gene Expression Regulation, Neoplastic*
  • Herpesvirus 4, Human / physiology*
  • Humans
  • Immunohistochemistry
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Polymerase Chain Reaction
  • Proto-Oncogene Proteins c-met / genetics*
  • Proto-Oncogene Proteins c-met / immunology
  • Proto-Oncogene Proteins c-met / metabolism*
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / virology*


  • Proto-Oncogene Proteins c-met