Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement

Magn Reson Med. 2002 Feb;47(2):372-83. doi: 10.1002/mrm.10051.


After administration of gadolinium, infarcted myocardium exhibits delayed hyperenhancement and can be imaged using an inversion recovery (IR) sequence. The performance of such a method when using magnitude-reconstructed images is highly sensitive to the inversion recovery time (TI) selected. Using phase-sensitive reconstruction, it is possible to use a nominal value of TI, eliminate several breath-holds otherwise needed to find the precise null time for normal myocardium, and achieve a consistent contrast. Phase-sensitive detection is used to remove the background phase while preserving the sign of the desired magnetization during IR. Experimental results are presented which demonstrate the benefits of both phase-sensitive IR image reconstruction and surface coil intensity normalization for detecting myocardial infarction (MI). The phase-sensitive reconstruction method reduces the variation in apparent infarct size that is observed in the magnitude images as TI is changed. Phase-sensitive detection also has the advantage of decreasing the sensitivity to changes in tissue T(1) with increasing delay from contrast agent injection.

Publication types

  • Comparative Study

MeSH terms

  • Artifacts
  • Contrast Media*
  • Coronary Disease / diagnosis*
  • Gadolinium DTPA*
  • Humans
  • Image Enhancement*
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging*
  • Myocardial Infarction / diagnosis*
  • Myocardium / pathology
  • Phantoms, Imaging
  • Reference Values
  • Sensitivity and Specificity


  • Contrast Media
  • Gadolinium DTPA