Neuroendocrine mechanisms in fibromyalgia-chronic fatigue

Best Pract Res Clin Rheumatol. 2001 Dec;15(5):747-58. doi: 10.1053/berh.2001.0191.


Fibromyalgia and chronic fatigue syndrome are poorly understood disorders that share similar demographic and clinical characteristics. Because of the clinical similarities between both disorders it was suggested that they share a common pathophysiological mechanism, namely, central nervous system dysfunction. This chapter presents data demonstrating neurohormonal abnormalities, abnormal pain processing and autonomic nervous system dysfunction in fibromyalgia and chronic fatigue syndrome. The possible contribution of the central nervous system dysfunction to the development and symptomatology of these conditions is discussed. The chapter concludes by reviewing the effect of current treatments and emerging therapeutic modalities in fibromyalgia and chronic fatigue syndrome.

Publication types

  • Review

MeSH terms

  • Autonomic Nervous System Diseases / complications
  • Autonomic Nervous System Diseases / physiopathology*
  • Central Nervous System Diseases / complications
  • Central Nervous System Diseases / physiopathology
  • Fatigue Syndrome, Chronic / etiology
  • Fatigue Syndrome, Chronic / physiopathology*
  • Fatigue Syndrome, Chronic / therapy
  • Fibromyalgia / etiology
  • Fibromyalgia / physiopathology*
  • Fibromyalgia / therapy
  • Humans
  • Hypothalamo-Hypophyseal System / physiopathology
  • Neurosecretory Systems / physiopathology*
  • Pituitary-Adrenal System / physiopathology