Comparative analysis of FUR regulons in gamma-proteobacteria

Nucleic Acids Res. 2001 Dec 15;29(24):5195-206. doi: 10.1093/nar/29.24.5195.


Iron is an essential element for the survival and pathogenesis of bacteria. The strict control of iron homeostasis is mediated by the FUR repressor, which is highly conserved among various bacterial species. Here we apply the comparative genomics approach to analyze candidate Fur-binding sites in the genomes of Escherichia coli (K12 and O157:H7), Salmonella typhi, Yersinia pestis and Vibrio cholerae. We describe a number of new loci encoding siderophore biosynthesis and transport proteins. A new regulator of iron-acquisition systems was found in S.typhi. We predict FUR regulation for several virulence systems. We also predict FUR regulation for the chemotaxis system of V.cholerae that is probably involved in the process of pathogenesis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bacterial Proteins / genetics*
  • Escherichia coli / genetics
  • Escherichia coli / metabolism
  • Gammaproteobacteria / genetics*
  • Gammaproteobacteria / metabolism
  • Genes, Bacterial / genetics
  • Genome, Bacterial
  • Iron / metabolism*
  • Molecular Sequence Data
  • Repressor Proteins / genetics*
  • Salmonella typhi / genetics
  • Salmonella typhi / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Vibrio cholerae / genetics
  • Vibrio cholerae / metabolism
  • Yersinia pestis / genetics
  • Yersinia pestis / metabolism


  • Bacterial Proteins
  • Repressor Proteins
  • ferric uptake regulating proteins, bacterial
  • Iron