Wilms' tumor in adults: aspiration cytology and cytogenetics

Diagn Cytopathol. 2002 Feb;26(2):99-103. doi: 10.1002/dc.10048.


The fine-needle aspiration cytologic findings of Wilms' tumor occurring in a 20-yr-old female patient and a 35-yr-old male patient showing blastemal, spindled sarcomatous and rare epithelial components are reported. The male patient had the typical presentation of renal mass with metastasis to lung and pleura, whereas the female patient had an unusual presentation with the tumor originated from the subcapsular nephrogenic zone of the kidney, extending into the liver without invasion into the renal cortex. Cytogenetic analysis of this case identified: 90, XXXX, +2x3-4, -5, -15, -16, -17, -17, i (17)(q10) x2. This finding may represent a genetic change associated with Wilms' tumor of older pediatric and young adult patients. To the best of our knowledge, this case is the sixth case with cytogenetic study and the first case revealing isochromosome 17q of an adult Wilms' tumor.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biopsy, Needle
  • Chemotherapy, Adjuvant
  • Chromosome Aberrations
  • Female
  • Humans
  • Karyotyping
  • Kidney Neoplasms / genetics
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / therapy
  • Liver Neoplasms / genetics
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / therapy
  • Lung Neoplasms / genetics
  • Lung Neoplasms / secondary*
  • Lung Neoplasms / therapy
  • Male
  • Nephrectomy
  • Pleural Neoplasms / genetics
  • Pleural Neoplasms / secondary*
  • Pleural Neoplasms / therapy
  • Wilms Tumor / genetics
  • Wilms Tumor / secondary*
  • Wilms Tumor / therapy