Abstract
Between 1989 and 2000, 21 fetuses were diagnosed with complete atrioventricular block. Seven women with fetal ventricular rates of less than 60 were given oral terbutaline, and 6 of these had an initial increase in the fetal ventricular rate. Four fetuses (57%) maintained an increased average rate of 60 beats per minute and survived. Two fetuses returned to rates below 55 and died. The final fetus, with hypertrophic cardiomyopathy, was unresponsive. Terbutaline, therefore, is initially effective in raising the fetal ventricular rate, but this effect may be transient.
MeSH terms
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Adrenergic beta-Agonists / therapeutic use*
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Dose-Response Relationship, Drug
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Echocardiography
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Female
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Fetal Diseases / diagnosis
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Fetal Diseases / drug therapy*
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Fetal Diseases / mortality
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Fetal Heart / abnormalities*
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Fetal Heart / diagnostic imaging
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Gestational Age
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Heart Block / diagnosis
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Heart Block / drug therapy*
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Heart Block / mortality
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Heart Rate / drug effects
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Heart Rate / physiology
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Humans
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Hydrops Fetalis / etiology
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Hydrops Fetalis / mortality
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Infant Welfare
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Infant, Newborn
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Male
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Noonan Syndrome / drug therapy
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Noonan Syndrome / etiology
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Noonan Syndrome / mortality
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Pennsylvania
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Pregnancy
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Pregnancy Complications, Cardiovascular / diagnosis
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Pregnancy Complications, Cardiovascular / drug therapy
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Respiratory Distress Syndrome, Newborn / drug therapy
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Respiratory Distress Syndrome, Newborn / etiology
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Respiratory Distress Syndrome, Newborn / mortality
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Survival Analysis
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Terbutaline / therapeutic use*
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Treatment Outcome
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Women's Health
Substances
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Adrenergic beta-Agonists
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Terbutaline