The effect of changes in depression on health related quality of life (HRQoL) in HIV infection

Gen Hosp Psychiatry. 2002 Jan-Feb;24(1):43-7. doi: 10.1016/s0163-8343(01)00174-8.


This study prospectively evaluated the effect of treatment of major depression on psychosocial functioning (health-related quality of life (HRQoL)). Previously, we reported on a trial of 75 HIV+ patients who were blindly randomized to receive treatment with drug or placebo (N=25 to each of paroxetine, imipramine, or placebo). Forty-one individuals completed the entire trial (placebo = 14, antidepressant = 27). In this study, we assessed HRQoL using the Quality of Life Enjoyment and Satisfaction Questionnaire (QLESQ) and the Social Adjustment Scale (SAS) at baseline and the end of the trial (12 weeks) using a random effects model to estimate treatment effects. HIV/AIDS patients with a major depressive disorder who completed the clinical trial demonstrated a reduction in depression with response to treatment and a significant improvement in HRQoL with the exception of work and financial functioning. Effective management of depression in HIV/AIDS patients is important, especially with the importance of adherence in current HIV/AIDS antiviral therapy. HRQoL improved in patients regardless of drug or response group and as a function of being in this trial suggesting that medications may not be required to affect HRQoL outcomes and that disease management aspects of care are important.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / psychology
  • Adult
  • Antidepressive Agents / therapeutic use
  • CD4 Antigens / immunology
  • Depressive Disorder, Major / drug therapy
  • Depressive Disorder, Major / immunology
  • Depressive Disorder, Major / psychology*
  • HIV Seropositivity / psychology*
  • Humans
  • Male
  • Paroxetine / therapeutic use*
  • Personal Satisfaction
  • Prospective Studies
  • Quality of Life*
  • Severity of Illness Index
  • Sickness Impact Profile*
  • Social Adjustment
  • Surveys and Questionnaires


  • Antidepressive Agents
  • CD4 Antigens
  • Paroxetine