[(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5

Bioorg Med Chem Lett. 2002 Feb 11;12(3):407-9. doi: 10.1016/s0960-894x(01)00767-3.

Abstract

The synthesis of a new potent, subtype-selective radioligand [(3)H]-M-MPEP (2-methyl-6-((3-methoxyphenyl)ethynyl)-pyridine) and its in vitro pharmacological characteristics are described. Science Ltd.

MeSH terms

  • Binding Sites
  • Binding, Competitive / drug effects
  • Humans
  • Kinetics
  • Ligands
  • Pyridines / pharmacology*
  • Radiopharmaceuticals / chemical synthesis*
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / antagonists & inhibitors
  • Receptors, Metabotropic Glutamate / metabolism*
  • Recombinant Proteins / metabolism

Substances

  • Ligands
  • Pyridines
  • Radiopharmaceuticals
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate
  • Recombinant Proteins
  • SIB 1893
  • 6-methyl-2-(phenylethynyl)pyridine