DNA-catalyzed polymerization

J Am Chem Soc. 2002 Feb 6;124(5):746-7. doi: 10.1021/ja017319j.


Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5'-amino-3'-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics to read the encoded sequence and chain-length information in the antiparallel direction. Single mismatches in the template are selected against at a level of >100:1. A method is therefore established to translate biopolymer-encoded information stereoselectively into sequence- and chain-length specific synthetic polymers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Catalysis
  • Chromatography, High Pressure Liquid
  • DNA / chemical synthesis*
  • DNA / chemistry*
  • Kinetics
  • Stereoisomerism
  • Substrate Specificity
  • Templates, Genetic


  • DNA