Intrathecal gadolinium-enhanced MR cisternography in the evaluation of clinically suspected cerebrospinal fluid rhinorrhea in humans: early experience

Radiology. 2002 Feb;222(2):555-9. doi: 10.1148/radiol.2222010249.


In this prospective multicenter study, the authors evaluated the utility of magnetic resonance (MR) cisternography after intrathecal administration of gadopentetate dimeglumine in 15 patients clinically suspected of having cerebrospinal fluid (CSF) rhinorrhea. By means of lumbar puncture, a single dose of 0.5 mL of gadopentetate dimeglumine was injected into the lumbar subarachnoid space. Thirteen patients showed leakage of contrast material through the cribriform plate into the ethmoid or sphenoid air cells. No leakage was observed in two patients. The study results show the relative safety and feasibility of low-dose gadolinium-enhanced MR cisternography in confirming the presence and determining the focus of active CSF leaks.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cerebrospinal Fluid Rhinorrhea / diagnosis*
  • Child
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Humans
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Neuroradiography / methods
  • Prospective Studies
  • Tomography, X-Ray Computed


  • Contrast Media
  • Gadolinium DTPA