Kinetic amplification of enzyme discrimination

Biochimie. 1975;57(5):587-95. doi: 10.1016/s0300-9084(75)80139-8.


The dependence of the accuracy of enzymatic systems on the mechanism of the catalyzed reaction is investigated, using a probabilistic approach. Certain mechanisms of reaction, involving a delay in one of the steps act as kinetic amplifiers of molecular discriminations. The relationship between our scheme for a delayed reaction [1] and Hopfield's scheme [i] is discussed.

Publication types

  • Comparative Study

MeSH terms

  • DNA Nucleotidyltransferases
  • Enzymes*
  • Kinetics*
  • Models, Chemical
  • Probability
  • Structure-Activity Relationship


  • Enzymes
  • DNA Nucleotidyltransferases