Mapping and analysis of quantitative trait loci in experimental populations

Nat Rev Genet. 2002 Jan;3(1):43-52. doi: 10.1038/nrg703.


Simple statistical methods for the study of quantitative trait loci (QTL), such as analysis of variance, have given way to methods that involve several markers and high-resolution genetic maps. As a result, the mapping community has been provided with statistical and computational tools that have much greater power than ever before for studying and locating multiple and interacting QTL. Apart from their immediate practical applications, the lessons learnt from this evolution of QTL methodology might also be generally relevant to other types of functional genomics approach that are aimed at the dissection of complex phenotypes, such as microarray assessment of gene expression.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Algorithms
  • Animals
  • Chromosome Mapping / methods*
  • Gene Expression Profiling
  • Genetic Markers
  • Genetic Variation
  • Genotype
  • Humans
  • Linear Models
  • Mice
  • Models, Genetic
  • Oligonucleotide Array Sequence Analysis
  • Phenotype
  • Quantitative Trait, Heritable*


  • Genetic Markers