Sibling rivalry in the E2F family

Nat Rev Mol Cell Biol. 2002 Jan;3(1):11-20. doi: 10.1038/nrm714.


The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Cycle
  • Cell Cycle Proteins / physiology
  • Cell Differentiation
  • Cell Division
  • Chromatin / metabolism
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • E2F6 Transcription Factor
  • Gene Expression Regulation
  • Humans
  • Mice
  • Models, Genetic
  • Neoplasms / etiology
  • Protein Structure, Tertiary
  • Retinoblastoma Protein / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / physiology*


  • Cell Cycle Proteins
  • Chromatin
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • E2F6 Transcription Factor
  • E2F6 protein, human
  • E2f6 protein, mouse
  • Retinoblastoma Protein
  • Transcription Factors