Mechanisms of transcription-coupled DNA repair

Nat Rev Mol Cell Biol. 2002 Jan;3(1):21-9. doi: 10.1038/nrm703.


Several types of helix-distorting DNA lesions block the passage of elongating RNA polymerase II. Surprisingly, such transcription-blocking lesions are usually repaired considerably faster than non-obstructive lesions in the non-transcribed strand or in the genome overall. In this review, our knowledge of eukaryotic transcription-coupled repair (TCR) will be considered from the point of view of transcription, and current models for the mechanism of TCR will be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cockayne Syndrome / genetics
  • DNA Damage
  • DNA Repair*
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation
  • Humans
  • Models, Genetic
  • Nucleosomes / physiology
  • RNA Polymerase II / physiology
  • Transcription, Genetic*
  • Yeasts / genetics


  • DNA-Binding Proteins
  • Nucleosomes
  • RNA Polymerase II