Neurogenesis in adult primate neocortex: an evaluation of the evidence

Nat Rev Neurosci. 2002 Jan;3(1):65-71. doi: 10.1038/nrn700.

Abstract

Reports of continuous genesis and turnover of neurons in the adult primate association neocortex--the site of the highest cognitive functions--have generated great excitement. Here, I review the available evidence, and question the scientific basis of this claim.

Publication types

  • Review

MeSH terms

  • Animals
  • Antimetabolites / metabolism
  • Biomarkers
  • Bromodeoxyuridine / metabolism
  • Cell Cycle / physiology
  • DNA / metabolism
  • Macaca
  • Models, Neurological
  • Neocortex / cytology*
  • Neocortex / physiology*
  • Neuroglia / cytology
  • Neuroglia / physiology
  • Neurons / cytology
  • Neurons / physiology*
  • Nucleotides / metabolism

Substances

  • Antimetabolites
  • Biomarkers
  • Nucleotides
  • DNA
  • Bromodeoxyuridine