Abstract
Reports of continuous genesis and turnover of neurons in the adult primate association neocortex--the site of the highest cognitive functions--have generated great excitement. Here, I review the available evidence, and question the scientific basis of this claim.
MeSH terms
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Animals
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Antimetabolites / metabolism
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Biomarkers
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Bromodeoxyuridine / metabolism
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Cell Cycle / physiology
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DNA / metabolism
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Macaca
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Models, Neurological
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Neocortex / cytology*
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Neocortex / physiology*
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Neuroglia / cytology
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Neuroglia / physiology
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Neurons / cytology
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Neurons / physiology*
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Nucleotides / metabolism
Substances
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Antimetabolites
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Biomarkers
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Nucleotides
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DNA
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Bromodeoxyuridine