Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2001 Nov;103(3):201-9.
doi: 10.1023/a:1013047722865.

A 5-year Follow-Up Study for Distance Visual Acuity After Low Dose Radiation on Subfoveal Choroidal Neovascularization in Age-Related Macular Degeneration

Affiliations

A 5-year Follow-Up Study for Distance Visual Acuity After Low Dose Radiation on Subfoveal Choroidal Neovascularization in Age-Related Macular Degeneration

C Valmaggia et al. Doc Ophthalmol. .

Abstract

In a prospective study with a 5-year follow-up, we assessed the effect of a single series of low-dose radiation on the distance visual acuity in eyes with angiographically confirmed subfoveal choroidal neovascularization (CNV) in age-related macular degeneration (ARMD). The posterior pole of 12 eyes was treated with 5 Gy (4 x 1.25 Gy), and 34 eyes treated with 8 Gy (4 x 2 Gy). The best corrected distance visual acuity was measured at the time of treatment, and annually thereafter for 5 years. The study obtained complete follow-up for 11 patients in the 5-Gy group (nine classic, two occult CNVs), and 29 patients in the 8-Gy group (12 classic, 17 occult CNVs). At baseline, the mean distance visual acuity of the treated eyes was 0.16 (20/125) in the 5-Gy group, and 0.2 (20/100) in the 8-Gy group. Five years later, an average loss of 3.2 lines was present in the 5-Gy group, and 4 lines in the 8-Gy group. After 5 years, an average loss of 2 lines was found in a control group consisting of 18 second eyes with low stage dry ARMD, with a mean distance visual acuity of 0.5 (20/40) at baseline. Statistical analyses with Wilcoxon and Mann-Whitney U-tests showed that a single series of low dose radiation with either 5 Gy or 8 Gy was not able to stabilize the distance visual acuity of eyes with subfoveal CNV in ARMD during a 5-year follow-up.

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Adv Exp Med Biol. 1988;242:85-93 - PubMed
    1. Klin Monbl Augenheilkd. 1998 May;212(5):321-3 - PubMed
    1. Ophthalmologe. 1998 Nov;95(11):760-4 - PubMed
    1. Ophthalmology. 1998 Jan;105(1):24-30 - PubMed
    1. Doc Ophthalmol. 1997;93(4):317-26 - PubMed
Feedback