Roles of pancreatic polypeptide in regulation of food intake

Peptides. 2002 Feb;23(2):323-9. doi: 10.1016/s0196-9781(01)00604-0.


Pancreatic polypeptide (PP) is produced in pancreatic islets of Langerhans and released into the circulation after ingestion of a meal. Peripherally administered PP suppresses food intake and gastric emptying. On the other hand, central administration of PP elicits food intake and gastric emptying. Therefore, PP actions on food intake may be, in part, attributable to gastric emptying. PP transgenic mice exhibit decreases in both food intake and gastric emptying rate that were clearly reversed by anti-PP antiserum. PP is an anorexigenic signal in the periphery and an orexigenic signal in the central nervous system.

Publication types

  • Review

MeSH terms

  • Animals
  • Central Nervous System / metabolism
  • Dose-Response Relationship, Drug
  • Feeding Behavior / drug effects
  • Gastric Emptying / drug effects*
  • Mice
  • Mice, Transgenic
  • Pancreatic Polypeptide / metabolism*
  • Pancreatic Polypeptide / physiology*
  • Time Factors


  • Pancreatic Polypeptide