Assembly of the type III secretion needle complex of Salmonella typhimurium

Microbes Infect. 2002 Jan;4(1):75-82. doi: 10.1016/s1286-4579(01)01512-x.

Abstract

The type III secretion needle complex (NC) of Salmonella typhimurium is a complex secretory system that functions to translocate virulence proteins into eukaryotic cells. Evolutionarily it is related to bacterial flagella. Assembly of the NC occurs through ordered secretion, polymerization, and assembly, and requires the coordinated expression and association of over 20 different proteins. Recent progress in the understanding of the assembly and architecture of the NC is reviewed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Eukaryotic Cells / microbiology
  • Humans
  • Salmonella Infections / microbiology
  • Salmonella typhimurium / metabolism
  • Salmonella typhimurium / pathogenicity*
  • Virulence

Substances

  • Bacterial Proteins