G proteins and pheromone signaling

Annu Rev Physiol. 2002;64:129-52. doi: 10.1146/annurev.physiol.64.081701.133448.


All cells have the capacity to respond to chemical and sensory stimuli. Central to many such signaling pathways is the heterotrimeric G protein, which transmits a signal from cell surface receptors to intracellular effectors. Recent studies using the yeast Saccharomyces cerevisiae have produced important advances in our understanding of G protein activation and inactivation. This review focuses on the mechanisms by which G proteins transmit a signal from peptide pheromone receptors to the mating response in yeast and how mechanisms elucidated in yeast can provide insights to signaling events in more complex organisms.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • GTP-Binding Proteins / physiology*
  • Pheromones / physiology*
  • Saccharomyces cerevisiae / physiology*
  • Signal Transduction / physiology*


  • Pheromones
  • GTP-Binding Proteins