Effects of some amino acids on horizontal cells in the fish retina

J Neurosci Res. 1979;4(5-6):351-63. doi: 10.1002/jnr.490040504.


Effects of some amino acids on horizontal cells were examined in the fish (Eugerres plumieri) retina. L-aspartate (5 mM in concentration) and L-glutamate (10 mM) consistently depolarized all types of horizontal cells, although the effect of L-aspartate was more pronounced. gamma-Aminobutyric acid (GABA; 10 mM) consistently hyperpolarized the cone-connected L- and C-type horizontal cells, whereas the effect on the rod-connected cells was slight or nonexistent. The hyperpolarizing effect of GABA on the cone-horizontal cells was markedly diminished by picrotoxin (0.1 mM). Usually, glycine (10 mM) showed slight and variable effects. It merely depolarized some cone-horizontal cells but weakly hyperpolarized some rod-horizontal cells. In a few cases, however, glycine began to drastically hyperpolarize the cone-horizontal cells in retinas that had been repeatedly treated with certain agents used. Taurine and beta-alanine (10 mM each) had negligible effects, although the former slightly depolarized and the latter merely hyperpolarized both cone- and rod-horizontal cells.

MeSH terms

  • Amino Acids / pharmacology*
  • Animals
  • Aspartic Acid / pharmacology
  • Fishes / physiology*
  • Glutamates / pharmacology
  • Glycine / pharmacology
  • Membrane Potentials / drug effects
  • Photoreceptor Cells / drug effects*
  • Picrotoxin / pharmacology
  • Retina / drug effects*
  • Taurine / pharmacology
  • beta-Alanine / pharmacology
  • gamma-Aminobutyric Acid / pharmacology


  • Amino Acids
  • Glutamates
  • beta-Alanine
  • Picrotoxin
  • Taurine
  • Aspartic Acid
  • gamma-Aminobutyric Acid
  • Glycine