Protective effect of allopurinol in the renal ischemia--reperfusion in uninephrectomized rats

Gen Pharmacol. 2000 Oct;35(4):189-93. doi: 10.1016/s0306-3623(01)00105-7.


The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfunction, and histologic alterations was evaluated during the renal ischemia--reperfusion in uninephrectomized rats. Renal malondialdehyde and serum creatinine levels significantly increased after renal ischemia--reperfusion. However, the pretreatment with allopurinol demonstrated a protector effect in these parameters. Renal ischemia--reperfusion provoked a significant renal damage in the operated group. Tubular atrophy and interstitial fibrosis were attenuated by allopurinol when given prior to the surgery. In our study, allopurinol had a strong tendency to exert a beneficial effect during renal ischemia--reperfusion in uninephrectomized rats.

MeSH terms

  • Allopurinol / therapeutic use*
  • Animals
  • Creatinine / blood
  • Ischemia / drug therapy*
  • Kidney / blood supply*
  • Kidney / pathology
  • Lipid Peroxidation
  • Male
  • Nephrectomy
  • Rats
  • Rats, Wistar
  • Reactive Oxygen Species
  • Reperfusion
  • Xanthine Oxidase / physiology


  • Reactive Oxygen Species
  • Allopurinol
  • Creatinine
  • Xanthine Oxidase