Orexins and feeding: special occasions or everyday occurrence?

Regul Pept. 2002 Mar 15;104(1-3):1-9. doi: 10.1016/s0167-0115(01)00343-3.


Neurons expressing prepro-orexin, the precursor of orexin-A and -B, are found in the lateral hypothalamic area, a region classically implicated in driving feeding. Orexin-A induces feeding transiently when injected centrally, and food intake can be decreased when orexin action is disrupted by immunoneutralization of orexin-A, or by pharmacological blockade of orexin receptors, or by transgenic knockout of orexin. Here, we argue that orexin neurons may act to stimulate feeding in the short term, and that important regulatory signals may be a fall in plasma glucose (stimulatory), countered by satiety signals generated by eating, such as gastric distention (inhibitory).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blood Glucose / physiology
  • Carrier Proteins / biosynthesis
  • Carrier Proteins / physiology*
  • Eating / physiology*
  • Humans
  • Hunger / physiology
  • Hypothalamic Area, Lateral / metabolism*
  • Intracellular Signaling Peptides and Proteins*
  • Leptin / physiology
  • Neurons / metabolism*
  • Neuropeptides / biosynthesis
  • Neuropeptides / physiology*
  • Orexins
  • Satiety Response / physiology


  • Blood Glucose
  • Carrier Proteins
  • HCRT protein, human
  • Intracellular Signaling Peptides and Proteins
  • Leptin
  • Neuropeptides
  • Orexins