Roles of the Werner syndrome protein in pathways required for maintenance of genome stability

Exp Gerontol. 2002 Apr;37(4):491-506. doi: 10.1016/s0531-5565(01)00227-3.


Werners syndrome is a disease of premature aging where the patients appear much older than their chronological age. The gene codes for a protein that is a helicase and an exonuclease, and recently we have learned about some of its protein interactions. These interactions are being discussed as they shed light on the molecular pathways in which Werner protein participates. Insight into these pathways brings insight into the aging process.

Publication types

  • Review

MeSH terms

  • Catalysis
  • Chromosome Aberrations
  • DNA Helicases / genetics
  • DNA Helicases / physiology*
  • DNA Replication
  • Exodeoxyribonucleases
  • Humans
  • Mutation
  • Phenotype
  • Polymorphism, Genetic
  • RecQ Helicases
  • Tumor Suppressor Protein p53 / physiology
  • Werner Syndrome / genetics*
  • Werner Syndrome Helicase


  • Tumor Suppressor Protein p53
  • Exodeoxyribonucleases
  • DNA Helicases
  • RecQ Helicases
  • WRN protein, human
  • Werner Syndrome Helicase