Objective: To provide experimental basis for further study on the mechanism of diabetic cystopathy (DCP).
Methods: The bladder compliance and contraction/relaxation of whole bladder/detrusor strips were evaluated in vitro on diabetic rats.
Results: Significant decrease of detrusor contraction/relaxation and increase of bladder compliance were observed (P < 0.01). The contractile force of diabetes, diuresis and control were (20.80 +/- 6.38), (31.66 +/- 6.17) and (40.10 +/- 7.21) g/100 mg T respectively.
Conclusions: The results suggest that both the injury of detrusor contraction/relaxation and bladder compliance are important factors for diabetic cystopathy, however, diuresis does not play a major role in the development of DCP.