Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models

Cell. 2002 Jan 25;108(2):145-52. doi: 10.1016/s0092-8674(02)00622-0.


Cancer directly affects at least one-third of the human population, but the inherited genetic determinants of cancer risk remain largely unknown. Mouse models of human cancer are helping us to understand this disease as a complex genetic trait and thus to identify the multiple genetic variant alleles involved in pathways that affect individual cancer susceptibility.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alleles
  • Animals
  • Disease Models, Animal*
  • Genetic Predisposition to Disease*
  • Humans
  • Mice
  • Models, Biological
  • Neoplasms / genetics*
  • Quantitative Trait, Heritable
  • Risk Factors