Apoptosis: a link between cancer genetics and chemotherapy

Cell. 2002 Jan 25;108(2):153-64. doi: 10.1016/s0092-8674(02)00625-6.


Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of these defects chemotherapy often fails. Understanding the molecular events that contribute to drug-induced apoptosis, and how tumors evade apoptotic death, provides a paradigm to explain the relationship between cancer genetics and treatment sensitivity and should enable a more rational approach to anticancer drug design and therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Apoptosis* / drug effects
  • Drug Resistance, Neoplasm
  • Humans
  • Models, Biological
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Neoplasms / physiopathology
  • Signal Transduction / physiology


  • Antineoplastic Agents