The role of PML in tumor suppression

Cell. 2002 Jan 25;108(2):165-70. doi: 10.1016/s0092-8674(02)00626-8.

Abstract

The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Apoptosis / physiology*
  • Carrier Proteins / metabolism
  • Cell Division
  • Cell Transformation, Neoplastic*
  • Cellular Senescence
  • Genes, Tumor Suppressor / physiology*
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Neoplasm Proteins / genetics*
  • Neoplasm Proteins / metabolism
  • Neoplasm Proteins / physiology*
  • Neoplasms / genetics
  • Neoplasms / physiopathology
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism*
  • Promyelocytic Leukemia Protein
  • Receptors, Retinoic Acid / genetics
  • Receptors, Retinoic Acid / metabolism
  • Retinoic Acid Receptor alpha
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcription Factors / physiology*
  • Tumor Suppressor Protein p53 / metabolism
  • Tumor Suppressor Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • DAXX protein, human
  • Intracellular Signaling Peptides and Proteins
  • Neoplasm Proteins
  • Nuclear Proteins
  • Oncogene Proteins, Fusion
  • Promyelocytic Leukemia Protein
  • RARA protein, human
  • Receptors, Retinoic Acid
  • Retinoic Acid Receptor alpha
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • Tumor Suppressor Proteins
  • PML protein, human