[Calcium-dependent pathways involved in the production of cytokines in lymphocytes]

J Soc Biol. 2001;195(3):309-17.
[Article in French]


CD4+ T lymphocytes are divided in Th1 cells producing IFN gamma and Th2 cells that synthetize IL-4. This paper describes signaling pathways activated following T cell receptor (TCR) engagement and emphasizes differences that can account for differential cytokine production. This paper focuses on a new signaling pathway involved in IL-4 synthesis. This pathway couples the TCR to PKC that controls a calcium entry through dihydropyridine sensitive calcium channels. The calcium response is sufficient to initiate IL-4 gene transcription. Differing from that of IL-4, IFN gamma gene expression always requires MAP-kinase activation in addition to a calcium signal.

Publication types

  • Comparative Study
  • English Abstract
  • Review

MeSH terms

  • Calcium / pharmacology*
  • Cytokines / biosynthesis*
  • Humans
  • Interferon-gamma / biosynthesis
  • Interleukin-4 / biosynthesis
  • Lymphocytes / metabolism*
  • Protein Kinase C / metabolism
  • Receptors, Antigen, T-Cell / physiology
  • Signal Transduction
  • Th1 Cells / metabolism
  • Th2 Cells / metabolism


  • Cytokines
  • Receptors, Antigen, T-Cell
  • Interleukin-4
  • Interferon-gamma
  • Protein Kinase C
  • Calcium