Sleep deprivation in the rat: X. Integration and discussion of the findings. 1989

Sleep. 2002 Feb 1;25(1):68-87.


The results of a series of studies on total and selective sleep deprivation in the rat are integrated and discussed. These studies showed that total sleep deprivation, paradoxical sleep deprivation, and disruption and/or deprivation of non-rapid eye movement (NREM) sleep produced a reliable syndrome that included death, debilitated appearance, skin lesions, increased food intake, weight loss, increased energy expenditure, decreased body temperature during the late stages of deprivation, increased plasma norepinephrine, and decreased plasma thyroxine. The significance of this syndrome for the function of sleep is not entirely clear, but several changes suggested that sleep may be necessary for effective thermoregulation.

Publication types

  • Biography
  • Classical Article
  • Historical Article

MeSH terms

  • Animals
  • Body Temperature Regulation / physiology
  • Brain / physiopathology*
  • Circadian Rhythm / physiology
  • Electroencephalography / history
  • Energy Metabolism / physiology
  • Grooming
  • History, 20th Century
  • Norepinephrine / blood
  • Norepinephrine / history
  • Rats
  • Skin Diseases / etiology
  • Skin Diseases / history
  • Sleep Deprivation / history*
  • Sleep Deprivation / physiopathology
  • Sleep Stages / physiology
  • Stress, Physiological / history
  • Stress, Physiological / psychology
  • Thyroxine / blood


  • Thyroxine
  • Norepinephrine

Personal name as subject

  • Allan Rechtschaffen
  • Bernard M Bergmann
  • Carol A Everson
  • Clete A Kushida
  • Marcia A Gilliland